Most-read articles published in Journal of Cell Science in the previous month. Most-read rankings are recalculated at the beginning of the following month and are based on full-text and pdf views.
- Myosin VI facilitates connexin 43 gap junction accretion
- Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes
Summary: Mechanotrasduction pathways during adipocyte differentiation of mesenchymal stem cells are mediated by the focal adhesion protein vinculin in a manner that involves regulation of actin organization and TAZ nuclear localization.
- Stress-specific differences in assembly and composition of stress granules and related foci
Highlighted Article: Haploid cells were used to study stress-specific differences in the dynamics and composition of stress granule-like foci, the translation-related mechanisms of their assembly and their connection to cell survival.
- Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis
Summary: We uncover interactions between the transmembrane domains of the metalloproteinase ADAM17 and its partner molecule Rhbdf2 as being crucial for the regulation of ADAM17-dependent EGF-receptor and TNFα signaling.
- The Rap1–cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse
- Corneal epithelial stem cells and their niche at a glance
Summary: We summarise the role of the niche microenvironment in regulating corneal epithelial stem cells during homeostasis, repair and disease.
- Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA
Summary: Vimentin intermediate filaments control the activity of RhoA, and consequent stress fiber assembly and contractility by downregulating its guanine nucleotide exchange factor GEF-H1.
- Endocytic turnover of Rab8 controls cell polarization