Most-read articles published in Journal of Cell Science in the previous month. Most-read rankings are recalculated at the beginning of the following month and are based on full-text and pdf views.
- Actin visualization at a glance
Summary: Here, we present current approaches to visualize actin filaments, emphasizing the advantages and pitfalls of available tools to investigate F-actin not only in the cytoplasm, but also in the somatic cell nucleus.
- Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells
Summary: Δ40p53 exerts tumor suppressor activity that is associated with upregulation of p53-target gene expression and induces senescence in hepatocellular carcinoma cell lines.
- A proteomic approach to identify endosomal cargoes controlling cancer invasiveness
Highlighted Article: This paper describes a novel proteomic approach to identify pro-invasive cargoes, which we have used to determine that Rab17 controls Vamp8 levels to drive neuropilin-2 trafficking, promoting invasion.
- Phosphorylation of XIAP by CDK1–cyclin-B1 controls mitotic cell death
Summary: Phosphorylation of XIAP by CDK1–cyclin-B1 controls the onset of mitotic cell death, which is important for surveillance against defects in mitosis and the response to cancer drugs that target cell division.
- Mitochondrial dynamics in neuronal injury, development and plasticity
Summary: Mitochondrial dynamics, encompassing fission, fusion and transport of the organelle, is precisely regulated and plays important roles in the development and function of the nervous system.
- Tension regulates myosin dynamics during Drosophila embryonic wound repair
Highlighted Article: We quantify non-muscle myosin II dynamics during the coordinated cell movements that drive embryonic wound repair, and demonstrate that mechanical forces and phosphorylation regulate myosin turnover.
- Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes
Highlighted Article: Clasp2 is largely confined to the basal progenitor layer of the epidermis. This report shows that Clasp2 ensures mitotic fidelity and holds primary keratinocytes into an undifferentiated state.