Fig. 7. Expression of Wnt-5a improves the morphology of MCF-7 breast cancer cells to a more normal phenotype. (A) Morphology of control MCF-7 cells transfected with the vector alone. (B) Morphology of MCF-7 cells expressing Wnt-5a protein. The Wnt-5a-expressing MCF-7 cells grow as islands containing tightly associated cells and therefore they appear to have a higher density than that of control cells, despite the fact that an equal number of both cell populations were plated and grown for 16 hours.