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Fig. 2. Functional analysis of wild-type and/or mutant Cx26 co-expressed with wtCx43 or wtCx37 in Xenopus oocytes. The bars represent the junctional conductance established between two cells (mean±s.e.m.). The relative functional activity of gap junctional channels is given in percent. (A) Cx26 mutants are functionally inactive. (B) Cx26 mutants dominantly inhibit channel function of co-expressed wtCx26. (C) Cx26 mutants causing PPK/HI suppress channel activity of co-expressed wtCx43 (trans-dominant effect). (D) Cx26 mutants exert variable effects on the function of wtCx37 channels.