Fig. 1. Fission yeast mfr1 is related to ste9/srw1. (A) mfr1 belongs to the Fizzy-related family of APC activators. Phylogenetic tree using the clustal method with PAM250 residue weight table. (B) Protein sequence comparison between ste9 and mfr1. Black boxes indicate identity; asterisks indicate related amino acids. The homology between ste9 and mfr1 extends beyond the seven WD repeats, including domains I and II previously described (Cebolla et al., 1999).