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Fig. 7. Granular Cl- fluxes and pH affect the recruitment of secretory granules for release. (A-B) Increases in cell capacitance ({Delta}C) evoked by a train of ten voltage-clamp depolarizations from -70 mV to zero (500 milliseconds, 1 Hz) under control conditions (n=9), after addition of Mg-ADP (n=4), in the presence of simultaneously added tolbutamide (tb) and Mg-ADP (n=6), after inclusion of anti-hClC-3c (n=7), anti-hClC-3n (n=17) or CCCP (n=6) as indicated. (B) Average total increases in cell capacitance ({Delta}C) ± s.e.m. for experiments in (A). *P<0.05; **P<0.01, ***P<0.001.