Fig. 1. Major enzymatic function of PTEN. The tumor suppressor PTEN opposes the action of phosphoinositide 3-kinase (PI 3-kinase) by dephosphorylating the signaling lipid phosphatidylinositol (3,4,5)-trisphosphate.
Fig. 1. Major enzymatic function of PTEN. The tumor suppressor PTEN opposes the action of phosphoinositide 3-kinase (PI 3-kinase) by dephosphorylating the signaling lipid phosphatidylinositol (3,4,5)-trisphosphate.