Fig. 1. CHMP1 is a conserved eukaryotic protein. (A) Conceptual translation products CHMP1 and PRSM1 from alternative reading frames of the human PRSM1 mRNA. (B) Phylogenetic tree for CHMP1 and CHMP1.5 from human (H.s.), and CHMP1 from Drosophila melanogaster (D.m.), C. elegans (C.e.) and S. cerevisiae (S.c.). ClustalX was used to align proteins and calculate the distance between proteins for tree construction (Thompson et al., 1997). (C) All CHMP1 proteins from the tree are aligned. Amino acids that are identical in at least three proteins are highlighted.