Fig. 4. Phylogenetic relationship of the human type I and II keratins. The phylogenetic tree shown was generated following the alignment of human type I (A) and type II keratins (B). Multiple sequence alignments were performed using the CLUSTAL program. Evolutionary tree construction was prepared using the CLUSTREE program. For the alignment, sequences published in the human genome draft were used (International Human Genome Sequencing Consortium, 2001).