Fig. 10. Cytoplasmic domains of melanosomal, lysosomal and vacuolar transmembrane glycoproteins. Sequence alignment of the cytoplasmic domain of integral membrane proteins targeted to lysosomes/vacuole or melanosomes. Boxed are the di-leucine- and tyrosine-based sorting signals from the indicated proteins. The indicated numbers reflect the number of amino acids between two domains or two signals. The most conserved residues are indicated in bold. Sequences were obtained from GenBank.