Fig. 1. Conservation of phosphorylation site sequences within the MAP4 MT-binding domain. Comparison of amino acid sequences from human (Chapin et al., 1995), mouse (West et al., 1991), bovine (Aizawa et al., 1990), and Xenopus (Shiina et al., 1999) shows conservation of serines among species (696 and 787 positions in human MAP4 sequence), residing within proline-directed consensus sites for cyclin B-cdc2 kinase phosphorylation, highlighted in boxes. Identical amino acids among species are represented by bars and deletions by asterisks. Note that the region surrounding ser-696 is more highly conserved than that around ser-787.