Fig. 1. A schematic diagram of metazoan TAF_II250. Locations of enzymatic domains (N-terminal kinase domain (NTK), C-terminal kinase domain (CTK), histone acetyltransferase domain (HAT), and ubiquitin-activating/conjugating domain (E1/E2)) and bromodomains (Bromo) are indicated within the linear TAF_II250 protein. Substrates for the enzymatic activities are indicated above the TAF_II250 protein, and interacting proteins are indicated below the protein. Substrates and interacting partners are abbreviated as follows: TFIIA (A), TFIIE (E), TFIIF (F), TATA-binding protein (TBP), retinoblastoma protein (RB), HIV Tat (TAT) and TFIIF (RAP74).