Fig. 2. Post-mitotic differentiation of Fgf2 mutant MPC cells is severely altered. (A) Wild-type MPC cells grown under permissive conditions. (B) Fgf2 mutant MPC cells grown under permissive conditions. Note that these cells tend to grow more as aggregates than their wild-type counterparts. (C) Differentiated wild-type MPC cells (grown for 7 days under nonpermissive conditions). Inset shows a representative branched process of a differentiated wild-type MPC cell. (D) Differentiated Fgf2 mutant MPC cells. Inset shows the disruption of process formation (compare with inset in C). Diff, differentiated cells; Prol, proliferating cells.