Fig. 5. -Adrenergic induction of the hsp70 gene involves a PI 3-kinase. Pretreatment of transfected oyster hemocytes with the PI 3-kinase inhibitor LY294002 blocked the PE-induced increase in luciferase activity. Data are means and standard errors of three replicate experiments. Asterisks denote significant (P<0.01) differences from samples incubated in the presence of 1 µM PE alone. Bas indicates luciferase activity in samples incubated in the absence of drugs.