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Fig. 5. Phospholipase C inhibitor, U73122, blocked the chlorpromazine (CPZ)-induced reduction in tether force. Incubation of cells with 30 µM chlorpromazine induces a decrease in tether force. Tether force was measured 10-15 minutes after chlorpromazine addition. Chlorpromazine-induced decrease in adhesion energy is likely mediated by activation of PLC, as 1 µM U73122, a PLC inhibitor, blocked the chlorpromazine-induced decrease in tether force.