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Fig. 5. In vivo SPRR4 expression after chronic UV exposure. In situ hybridization was performed with SPRR4 sense (a,c,e,g) and antisense (b,d,f,h) probes. Results for chronic exposure from phototype II (a-d) and phototype III (e-h) volunteers, before (a,b,e,f) and after (c,d,g,h) the UV treatment are represented. Bar, 30 µm.