Fig. 3. Effect of MPB-91 on the calcium and swelling activated iodide efflux in IB3-1 cells. (A) Averaged iodide efflux curves showing the lack of effect of MPB-91 treatment on calcium-induced-iodide efflux (1 µM A23187 was used, n=4). (B) Demonstration of a small decrease of the volume-sensitive chloride transport observed after MPB-91 treatment (a 50% hypo-osmotic solution was present from the time indicated by the arrow to the end of the experiment, n=4). (C) Bar graphs presenting the effects of MPB-91 treatment on calcium and volume-sensitive chloride transport in IB3-1 cells. Arrows indicate the time of drug additions. NS, non-significant difference; *P<0.05.