Fig. 3. Cell-cycle progression in FPLD cells. (A) FACS analysis of fibroblasts from control individuals and patients JM (LaA/C R482Q) and LM (R482W). Data are the mean±s.e. of four different experiments, each being performed with cells from two control and two patients. Apo, apoptotic cells. (B) A living fibroblast from patient LM containing a dysmorphic nucleus was observed by phase contrast and microcinematography. Note the stability of the nuclear morphology over a 28 hour period and the ability of the cell to divide. Bar, 10 µm.