Fig. 8. Silencing of the cyclin-dependent kinase 1 (cdk1). HeLa cells were transfected with cdk1 siRNA (A,C,D) or with luciferase siRNA (B) and stained for lamin A/C (A-C). Cells transfected with cdk1 siRNA round up. Higher magnification shows that the lamina of these cells starts to depolymerize (C). (D) Phase-contrast of HeLa cells 2 days after transfection with cdk1 siRNA. Magnification 480x (A,B); 760x (C); 300x (D).