JCS -- Mochizuki et al. 115 (1): 175 Figure IG8

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Fig. 8. Ang2-mediated tube formation is not dependent on PI 3-kinase. Treatment of IBE cells with PI 3-kinase inhibitor LY294002 (A) or FesKE5-8 cells, which have a dominant-negative effect on PI 3-kinase activation by Ang2 (B) form tube-like structures in the presence of 1 µg/ml Ang2. Representative data were obtained from two independent experiments.