Fig. 10. Reduced staining of laminin-1 in human breast cancer. Cryostat sections of terminal duct lobular unit (TDLU) (a), a ductal carcinoma in situ (DCIS) (b) and four different infiltrating ductal breast carcinomas (IDC) (c-f) stained with immunoperoxidase for laminin-1 and counterstained with hematoxylin. In the TDLU a strongly stained, continuous basement membrane is delineated at the stromal (S)-epithelial (E) interface (a). In carcinomas, laminin-1 staining is localized to the stromal (S)-cancer epithelial (C) interface, but is discontinuous and less pronounced. (bar, 25 µm).