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Fig. 1. Domain structure of myne-1. (A) The predicted domain structure of myne-1 is shown. It includes seven spectrin repeats (large gray bars) and a transmembrane domain (black bar) at the C-terminus. Between the fifth and sixth spectrin repeat is a region (small gray bars) with homology to the LEM domain found in LAP2, emerin and MAN1. The LEM domain of myne-1 is interrupted in its midportion by an {alpha}-helical domain (white bar). Just before the transmembrane domain is a serine-rich domain (hexagon). (B) This region is not present in one splice form of myne. (C) The amino-acid sequence of the interrupted LEM domain of myne-1 is shown. The alignment of the LEM domains of human MAN1, emerin, LAP2, and two C. elegans homologs (F42H11.2/CAEEL; W01G7.5/CAEEL) is shown. Light gray represents homology; dark gray represents identity.