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Fig. 6. Gains or losses of Crb function cause dorsal closure defects. (A) A dorsolateral view of wild-type embryonic cuticle. (B) A dorsolateral view of cuticle of GAL4332.3/UAS-crbwt embryo showing a dorsal hole resulting from overexpression of wild-type Crb in the amnioserosa. (C) Dorsal view of wild-type embryonic cuticle. (D) Dorsal view of cuticle of embryo homozygous for crbS010409, showing dorsal hole and germband retraction defect.