Fig. 6. Map position and protein structure of cyk-3. (a) cyk-3 maps to the central region of chromosome III, between the breakpoint of sDf125 and sma-4. The large genomic locus contains 14 exons coding for a 1175 amino-acid protein with two conserved domains, an N-terminal EF-hand domain and a C-terminal UCH domain consisting of a Cys-Box (UCH1) and a His-box (UCH2). (b) The CYK-3 protein sequence. The two residues marked with black boxes indicate the position of the point mutations leading to premature STOP codons in the alleles t1525 (pos 98) and t1535 (pos 720). The predicted EF-hand domain is underlined in blue; the predicted UCH domain is underlined in red.