Fig. 1. (A) Constructs for multimeric FN7-10 (see Materials and Methods for details). (B) A scale model of the FN7-10 trimer, constructed from the coordinates of FN7-10 (Leahy et al., 1996) (these were also used to model the six FN-III domains in TNfn3-8) with the program RasMol (Sayle and Milner-White, 1995). The FN3 domains are shown as a spacefilling atomic model, and the -helices of CMP are indicated schematically in a ribbon format. For comparison an integrin molecule is drawn to scale (Carrell et al., 1985; Nermut et al., 1988).