Fig. 4. Two hours after a BrdU pulse, wild-type mice showed 8% labelled basal cells (A), while more than 50% of basal cells were labelled in K10^-/- mice (B). 24 hours after the pulse the wild-type showed predominantly labelling of daughter cells in the basal layer (C). In contrast, K10^-/- mice showed massive suprabasal labelling (D) indicating increased turnover of keratinocytes. The line depicts the dermo-epidermal junction. Bar, 40 µm.