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Fig. 3. Proliferation in cultured progenitor cells. (A) Cell colonies formed by third passage progenitor cells under limiting dilution conditions. The top left panel shows phase microscopy. Other panels show glycogen, G-6-P and GGT expression. (B) Growth factor responsiveness of progenitor cells. DNA synthesis rates following stimulation with HGF, TGF{alpha} and EGF increased in rat hepatocytes but progenitor cells responded to TGF{alpha} and EGF only.