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Fig. 1. Absence of SPARC results in cortical cataract. Slit-lamp photographs of wt mice (+/+) at 1, 3 and 7 months of age and SPARC-null mice (-/-) at 1, 3 and 7 months are shown. The SPARC-null lens at 1 month shows anterior subcapsular cortical opacity (arrow). SPARC-null lens at 3 months displayed anterior and posterior subcapsular opacity (arrows), whereas the nucleus is transparent. The SPARC-null lens at 7 months has a mature cataract (arrow). Arrowheads indicate the cornea, and arrows indicate lens opacity. mo, month. Bar, 240 µm.