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Fig. 1. (A) The CLUSTALX-analysis of the indicated amino acid sequences demonstrates the two classes of Ubc6-related proteins. (B) Comparison of the amino acid sequences of scUbc6p, mmUbc6p and hsUbc6ep. The CLUSTALW-alignment displays the well-conserved N-terminal Ubc domain (marked by a dotted line) and the less conserved tail region in both Ubc6 subfamilies. The conserved active site cysteine is indicated by an asterisk and the region of the membrane spanning domains is underlined.