Fig. 2. Structure and relatedness of LTBPs. (A) Schematic illustration of the structures of human LTBP 1-4 and an alternative hL3+EGF splice variant. hL3+EGF contains an additional Ca²⁺-binding EGF-like repeat between the 13th and the 14th repeat units. The protein domains, which were included in phL3/911-1153 cDNA construct used in recombinant protein production for immunizations, are also illustrated. (B) A dendrogram showing the relationships and similarity percentages between the protein sequences of human LTBP 1-4 and mouse Ltbp-3. The amino acid sequences were retrieved from GenBank and aligned with ClustalX. The alignment is displayed by TREEVIEW.