Fig. 9. Schematic representation of PCTAIRE-1 compared with PCTAIRE-2 and -3. (A) On the left-hand side of the sketch the three known PCTAIREs are aligned with their catalytic kinase domain represented as a grey box. On the right hand side, PCTAIRE-1 is depicted again with regions of high homology between all three genes in a black box, and those between PCTAIRE-1 and -2 in a grey box. Additionally, the ATP-binding site and the T-loop residue, as well as the residues phosphorylated by PKA, are shown along with their function for PCTAIRE-1. (B) Alignment of the PCTAIRE-1 region surrounding the residues involved in 14-3-3 binding, S119 and S153, with a dimeric 14-3-3 peptide inhibitor [difopein (Masters and Fu, 2001)]. The position of S119 and S153 are marked with asterisks. Identical residues are connected with a bar, and related residues with a colon.