Fig. 10. Both endogenous and exogenously added FGF-2 do not stimulate proliferation activity of CHO cells. CHO_FGF-2-GFP cells were spread on culture plates at a confluency of about 5-10%. Cell proliferation was monitored for 48 hours in the presence of recombinant His₆-FGF-2 (5 µg/ml; dotted line); in the presence of doxicyclin to induce FGF-2-GFP expression and externalization (solid line); or in the absence of doxicyclin as a control condition (dashed and dotted line).