Fig. 3. Mechanisms of matrix contact assembly and remodelling (A) in a podosome and (B) in a focal adhesion. The inset in B shows the positive and negative actions of protein complexes formed on paxillin subsequent to phosphorylation of residues Y31 and Y118 by focal adhesion kinase. The green circle and yellow oblong represent proximal components of the focal adhesion linker complex such as talin and filamin. Asterisks indicate activated forms of c-Src, Pyk2 and Pak.