Fig. 10. Double genomic in situ hybridization for MBP and PLP genes. Genomic in situ hybridization with the X-linked PLP gene being detected with FITC-labeled PLP probe (green) and the autosomal MBP gene being simultaneously detected with a digoxigenin-labeled MBP probe (red). In progenitors (Fig. 10A, phase-contrast 10C) and in oligodendrocytes (10B, phase contrast 10D), the PLP and the MBP genes were spatially separated. Bar, 10 µm.