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Fig. 6. Increased apoptosis in RANKL-treated Jnk1-/- BMMs. (A) TUNEL staining of BMMs isolated from Jnk1-/- and wild-type mice cultured in the presence of M-CSF or M-CSF and RANKL for 2 days and restimulated for 12 hours by the indicated cytokines. (B,C) Quantification of the apoptotic index in BMMs isolated from Jnk1-/- or Jnk2-/- male (B) or Jnk1-/- female (C) mice compared with wild-type (wt) mice. (D) Quantification of the apoptotic index in BMMs isolated from JunAA/JunAA compared with JunAA/wt male mice. The stars indicate the statistical significance: (***) P<0.0001, (**) P<0.001; (ns) non-significant.