JCS -- Brose and Rosenmund 115 (23): 4399 Figure IG4

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Fig. 4. Model of Munc13-1 activation by DAG. See text for details. Note that only one mechanism of DAG synthesis (i.e. PI-PLCß) is depicted here. Other PI-PLC activities are likely to also activate Munc13s. Indeed, PI-PLC ${delta}$ may be responsible for activation of Munc13-1 during high-frequency stimulation and intrasynaptic accumulation of Ca²⁺.