Fig. 9. ES-cell-derived chondrocytes display a differentiation plasticity. As shown in this paper ES cells differentiate in vitro into chondrocytes as well as osteocytes and into chondrocytes, which transdifferentiate into osteocytic cells. Chondrocytes isolated from EBs after initial dedifferentiation in culture, redifferentiate into chondrocytes and transdifferentiate mainly into adipocytes.