Fig. 1. Phylogenetic tree of the common pyridine nuleotide disulphide oxidoreductase domain. The limits are taken on the mouse AIF gene (offical name PCD8_MOUSE, positions 120 to 477). The alignment and the phylogenetc tree have been performed with the Clustal program, and the figure was produced with Treeview. Species names have been abbreviated according to the Swiss-Prot nomenclature. Upper case letters indicate the Swiss-Prot identification, while lower case letters correspond to mnemonic identification. aif_anoga, aif_tetng, AIF (Tetraodon nigroviridis); aif_caeel, Q9U229 (C. elegans); aif_disdi, Q9GRX6, AIF (D. discoideum); aif_fugru, AIF (Fugu rubripes); amid_human, AMID (Homo sapiens); amid_mouse, AMID (Mus musculus); dhna_synp7, Q935X8 (Synechococcus sp.); DLD1_PSEPU, dihydrolipoamide dehydrogenase (Pseudomonas putida); DLDH_BACST, dihydrolipoamide dehydrogenase (Bacillus stearothermophilus); DLDH_PEA, dihydrolipoamide dehydrogenase (Pisum sativum); DLDH_PSEFL, oxoglutarate dehydrogenase complex (Pseudomonas fluorescens); DLDH_YEAST, dihydrolipoamide dehydrogenase (Saccharomyces cerevisiae); EAA12325, (Anopheles gambiae); ferre_pseusp, Q52437, ferredoxin reductase (Pseudomonas sp.); ferre_rhoer, O69367, ferredoxin reductase (Rhodococcus erythropolis); ferre_xenla, O42346, neurula-specific ferrodoxin reductase-like protein (Xenopus laevis); FLRR_ECOLI, flavorubredoxin reductase (E. coli); GSHR_ECOLI, glutathione reductase (E. coli); GSHR_HUMAN, glutathione reductase (H. sapiens); gshr_rat, O89049, thioredoxin reductase (R. norvegicus); hyp_anasp, Q8YRY5 (Anabaena sp.); hyp_caeel, Q19655 (C. elegans); hyp_drome, O77266 (D. melanogaster); hyp_human, Q96NN9 (H. sapiens); hyp1_arath, Q9LXP4 (Arabidopsis thaliana); hyp2_arath, Q9C574 (A. thaliana); mdha_mescr, Q93YG1, monodehydroascorbate reductase (Mesembryanthemum crystallinum); mdha_orysa, Q8S3R2, putative cytosolic monodehydroascorbate reductase (Oryza sativa); mdha-arath, P92947, monodehydroascorbate reductase (A. thaliana); nadhd_anasp, Q8YPU6, NADH dehydrogenase (Anabaena sp.); nadhox_aquae, O67007, NADH oxidase (Aquifex aeolicus); nadhox_enthi, Q8WR54, NADH oxidase (Entamoeba histolytica).; nadhox_pyrab, Q9V0X9, NADH oxidase (Pyrococcus abyssi); nadhox_pyrfur, Q8U0Q3, NADH oxidase (Pyrococcus furiosus); NAPE_ENTFA, NADH peroxidase (Enterococcus faecalis); nitre_ecoli, Q8XEE3, nitrite reductase (NAD(P)H) subunit. (E. coli); nitre_picpa, Q9URM3, nitrite reductase (Pichia angusta); om_neime, OUTER MEMBRANE PROTEIN (Neisseria meningitidis); PCD8_DROME, AIF (Drosophila melanogaster); PCD8_HUMAN, AIF (H. sapiens); PCD8_MOUSE, AIF (Mus musculus); PCD8_RAT, AIF (Rattus norvegicus); PsbAa_rhopa, Q9XDW7 (Rhodopseudomonas palustris); rubre_rhilo, Q98BL3, rubredoxin reductase (Rhizobium loti); TYTR_CRIFA, trypanothione reductase (Crithidia fasciculata); TYTR_TRYCR, trypanothione reductase (Trypanosoma cruzi).