Fig. 9. Quantification of in situ hybridisation of islet-1 and components of the retinoid signalling pathway in the motoneurons in aged-matched normal and motoneuron disease patients compared to gapdh. Columns: 1, islet-1 expression in motoneurons of normal cord; 2, islet-1 expression in motoneurons of diseased cord; 3, RAR expression in motoneurons of normal cord; 4, RAR expression in motoneurons of diseased cord; 5, raldh-2 expression in motoneurons of normal cord; 6, raldh-2 expression in motoneurons of diseased cord. Error bar=s.e.m. There was a significant difference between islet-1 expression (columns 1 and 2), RAR expression (columns 3 and 4) and between raldh-2 expression (columns 5 and 6) ^*P<0.05 of normal and diseased aged matched samples. Students t-test, n=10.