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Fig. 5. Suppression of Myr-Chat-mediated Rap1 activation by dominant-negative mutants of Cas, Crk or C3G. 293T cells were co-transfected with Myr-Chat and Cas, Crk or C3G mutant expression plasmid. After 30 hours, the Rap1 activation level of these transfected cells was examined. Co-expression of Cas {Delta}SD (Myr+{Delta}SD), Crk W169L (Myr+W169L) or C3G dCD (Myr+dCD) effectively suppressed the Rap1 activation induced by Myr-Chat.