Fig. 1. Comparison of EGF-like proteins from apicomplexan parasites. (A) Apicomplexan proteins containing EGF-like domains. P. falciparum merozoite surface antigen PfMSP1, P. falciparum circumsporozoite protein PfCSP, Plasmodium ookinete surface antigens PfP21/P25, P. falciparum 125 kDa protein, Pf125 (PFC1045C, ACO97302), E. tenella microneme protein EtMIC4, and T. gondii microneme proteins TgMIC3, TgMIC6, TgMIC7, TgMIC8 and TgMIC9. (B) Amino acid sequences alignment of the cytoplasmic tails of transmembrane microneme proteins across the Apicomplexa. The amino acids colored in green correspond to the membrane-spanning domain and terminate with an almost strictly conserved tyrosine residue in blue. The conserved tryptophan residue is colored in red. (C) Alignment of the lectin-like domains present on TgMIC3 (TGO132530), TgMIC8 (AAK19757), NcMIC3 and E. tenella ESTs.