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Fig. 1. Sequence characteristics of TRAFs. (A) Domain organization of the mammalian TRAFs. R, RING domain; Z, zinc-finger domain; C-C, coiled-coil domain; TRAF-C, TRAF-C domain. The TRAF domain comprises the coiled-coil domain and the TRAF-C domain. (B) The proposed evolutionary tree for the mammalian, Drosophila and C. elegans TRAFs. This figure is adapted from Grech et al. (Grech et al., 2000).