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Fig. 5. FGFR3 and Brachyury are involved in an autoregulatory loop. (A) RT-PCR analyses of FGFR3 and Brachyury mRNA levels in mesenchymal progenitors C3H10T1/2 expressing recombinant FGFR3 (C3H10T1/2-FGFR3) or Brachyury (C3H10T1/2-Brachyury). (B) Smad1-signaling is not sufficient for Brachyury and FGFR3 but is sufficient for osteocalcin expression, as shown by RT-PCR analyses of FGFR3 and Brachyury mRNA levels in mesenchymal progenitors C3H10T1/2 expressing the biologically active Smad1-MH2 domain (C3H10T1/2-Smad1-MH2).