Fig. 6. Stimulation of phagocytosis of soft particles by LPA. (a) Opsonized beads were incubated with 3 µM LPA before presenting to murine macrophages and the phagocytic index determined as in Fig. 1. The data were compiled from four independent experiments, error bars indicate the standard deviation between experiments. LPA-stimulated the ingestion of opsonized soft beads, but not soft beads labeled with BSA alone. LPA also induced a concentration of actin filaments beneath soft beads (c, arrows), when compared with the control (b, arrows). Bar, 3 µm.