Fig. 3. ida encodes an APC5 homolog. (A) IDA coding information is in uppercase letters. 5'-untranslated, 3'-untranslated, and the DNA for the single intron are in lowercase letters. Amino acid residues are in three-letter code. Numbers to the right represent nucleotide position (upper) relative to the end of dSc2, and amino acid position (lower) relative to the putative IDA start. The presumed polyA signal is bold and underlined. A blue box outlines the putative TPR domain. A pink box demarcates putative phosphorylation sites that are lost in the nonsense mutation of the ida^b4 allele (asterisk, see text for details). The GenBank accession number for ida is AF312026. (B) An alignment of putative TPR domains in APC5 homologs from Drosophila, H. sapiens, S. cerevisiae and C. elegans is presented. Red residues are identical in all species, orange residues indicate that at least two species share identity, and yellow indicates similar residues.