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Fig. 1. (A) Time course of EC morphogenesis illustrating the formation of vacuoles and lumens in three-dimensional collagen matrices. Arrowheads indicate vacuole structures (8 hr) and nuclei (48 hr); arrows indicate lumen structures. Bar=50 µm. (B) Electron micrographic images of ECs undergoing morphogenesis in three-dimensional collagen matrices. Bar=5 µm.