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Fig. 3. A model of mammalian Musashi1 function in the regulation of the Notch1 signalling in mammals. (A) m-Numb blocks activation of the Notch signal (blocking cleavage and/or nuclear translocation with RBP-J{kappa}, among other events) by Notch ligands (Delta and Jagged), which are expressed in neighboring cells. (B) In Musashi1-expressing immature cells, mammalian Musashi1 activates Notch1 signaling through the translational repression of m-Numb. This potentiation of Notch1 signal by Musashi1 should maintain the immature proliferation status of cells expressing Musashi1. A vertical arrowhead shows the Notch1 intracellular cleavage cite.