Fig. 1. The structural similarity between C. elegans FEH-1 and mammalian Fe65, Fe65-L1 and Fe65-L2 proteins. (A) The FEH-1 sequence is deduced from translation of the putative exon I of feh-1 (italic characters) and of the yk423e6 cDNA clone (bold characters). Methionines 1 and 142 are underlined on the FEH-1 sequence. The alignment of FEH-1 with mammalian Fe65s has been performed with ClustalW. The sequence identities are shown by black boxes; at the bottom of each line, the asterisks (^*) indicate matching amino acids; the double dots (:) show strong amino acid similarities, whereas the dots (.) indicate weaker similarities. The positions of the WW, PTB1 and PTB2 domains are indicated. (B) Schematic representation of FEH-1 and mammalian Fe65s. The size of the spacers between the WW and the PTB1 domains, or the PTB1 and the PTB2 domain, is comparable among the four proteins, and the N- and the C-terminal regions of FEH-1 are similar in length to Fe65 and Fe65-L1.