Fig. 1. Melanocytes extend long filopodia from dendrite tips that transport melanosomes to keratinocytes. (a) Two melanocyte dendrites with prominent filopodia (fp; arrowhead) are shown in images taken at 8 seconds. The arrowheads point to thin structures consistent with filopodia. (b) A melanosome (circle) is present in a filopodia (fp) and moves towards the keratinocyte membrane (KM; outlined in hatched line). Over the course of 16 seconds the melanosome has moved along a filopodia towards the keratinocyte membrane. (c) The tip of a melanocyte dendrite is shown with multiple connections with a keratinocyte membrane (KM; outlined in hatched line). A melanosome (circle) moves towards the KM over the course of 40 seconds. (d) Two sequential images captured 5 minutes after treatment of cells with nocodazole are shown. Melanosomes have redistributed towards the melanocyte cell body, leaving a dendrite that appears empty. Filopodia (arrowhead) were not affected by nocodazole treatment.