Fig. 4. Backward movement of an acentric fragment was mediated by its telomere. (A-D) Selected frames from a time-lapse recording of a double-cut operation. (A) Before the first cut. (B) After the first cut, the fragment (arrow) moved backwards. (C) After the second cut, the telomere-containing fragment (arrowhead) continued moving backwards, but the interstitial fragment (arrow) halted at the location of the second cut. Times are given in minutes and seconds. Bar, 5 µm (D).