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Fig. 3. Proposed model for caspase activation: (1) Bcl-2 prevents Bax/Bak aggregation, probably indirectly; (2) BH3-only proteins inactivate Bcl-2-like molecules; (3) Bax/Bak aggregation either allows cytochrome c release by forming pores in the outer mitochondrial membrane or provides a platform for initiator caspase (X) activation through an unidentified Ced-4-like adapter (X).